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Abbott laboratories H3R antagonist (A-331440) was found to have the potential for genotoxic effects which prohibited its further development as an anti-obesity therapeutic (184)
They function by mimicking the activities of the body's natural GLP-1 hormone, which decreases appetite and manages blood sugar levels
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Kahles F, Liberman A, Halim C, Rau M, Mollmann J, Mertens RW, Ruckbeil M, Diepolder I, Walla B, Diebold S, et al
The side effects of BPC-157 are listed below
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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