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In contrast, chronic elevations in TMAO, a metabolite derived from LC, have been linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD), particularly in older adults with compromised renal function [64, 65]

Although the crude incidence rate was higher among semaglutide users, these participants were older and had substantially higher prevalences of diabetes, obesity, heart disease, and other conditions associated with mortality

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Weight gain, sleep, and joint pain are mostly other things

After 4 weeks, the dose is usually increased to 5mg per week, based on your clinicians advice