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The risk of renal adverse reactions was increased in patients with a history of renal impairment (the weight management trials included 65 patients with a history of moderate or severe renal impairment at baseline), and occurred more frequently during dose titration

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study on Leydig cells found that testosterone recovery in aged mice required weeks of tissue microenvironment improvement following senescent cell clearance (Zhang et al., 2020)

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The regulatory landscape has shifted significantly, with the FDA removing tirzepatide from the drug shortage list and restricting compounding under certain conditions