4e (middle)
We propose that curcumin exerts its broad therapeutic effects via a unified inflammationoxidative stress axis, primarily by inhibiting NF-B and NLRP3 activation, reducing ROS and pro-inflammatory cytokines (TNF-, IL-1/18), as seen across models of depression, metabolic disorders, and neurodegeneration
Zhang N
The next diversification event would have separated the remaining two groups, and these two groups were sister groups from each other
Nuclear factor-kappa B (NF-B) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, as well as genes involved in cell proliferation, adhesion, survival, and differentiation
Glutathione offers a range of benefits for the skin, from brightening and anti-aging effects to antioxidant protection and detoxification