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In addition, PFOS induces autophagy-associated apoptosis through ROS-mediated ERK1/2 activation, which is followed by the blockade of the normal autophagic flux in RTCs 3

Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

This decline contributes to multiple hallmarks of aging including decreased muscle mass and strength, increased fat accumulation, reduced bone density, impaired cognitive function, and compromised immune system performance

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Li C, Liao W, Wu M, Chu P

[53] [54] This is because it requires significant damage to the liver to impair bilirubin excretion, hence minor impairment (in the absence of biliary obstruction or Gilbert syndrome) would not lead to jaundice