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Digestive Comfort Some users report mild digestive upset, such as bloating or abdominal cramps, when taking high doses of standard oral glutathione

Hypoglycemia: While less common than with some other diabetes medications, Semaglutide can cause low blood sugar levels (hypoglycemia), especially when combined with other glucose-lowering therapies

Drug-induced acute pancreatitis: prevalence, causative agents, and outcomes

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Current UK professional guidance emphasises: Patients should inform their surgical team and anaesthetist that they are taking a GLP-1 medication as soon as surgery is planned Healthcare professionals should specifically ask about GLP-1 use during preoperative assessment, as patients may not recognise these medications as relevant to their surgery The decision to continue or pause GLP-1 therapy should be made on an individual risk-based assessment , considering the type of surgery, the specific GLP-1 agent, dose escalation status, presence of gastrointestinal symptoms, and the patient's clinical circumstances Many patients can safely continue GLP-1 medications perioperatively with appropriate precautions, while those at higher risk may benefit from temporary cessation The Summary of Product Characteristics (SmPC) for GLP-1 medications notes the delayed gastric emptying effect, which anaesthetists consider when planning perioperative care