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Its important to note that: Not all tiredness is caused by vitamin B12 deficiency
Extracellular Cu 2+ binding to ceruloplasmin is reduced by the metalloreductase six-transmembrane epithelial antigen of the prostate (SETAP) to Cu + , and copper transporter 1 (CTR1) (also known as solute carrier family 31 member 1, SLC31A1) transports Cu + into cells (Ohgami et al., 2006)
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