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A decreased risk of PD development was also reported to be linked to higher serum UA levels (Sarukhani et al., 2018)

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3.5 Hypothalamic-pituitary-ovarian axis disruption Disruption of gut microbiota leading to systemic LPS translocation not only impairs peripheral organ function but also exacerbates PCOS pathology by interfering with the neuroendocrine regulation of the HPO axis (56)

As a novel antidiabetic agent, glucagon-like peptide-1 (GLP-1) exerts a renoprotective effect in DKD rats via activation of autophagy through AMPK-mTOR pathway (155)

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