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In the REDEFINE 1 DXA subgroup roughly a third of the weight lost was lean soft tissue, so resistance training and high protein are part of this protocol

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R 1 is a proxy of rCBF with good agreement with rCBF measures obtained by [ 15 O]H 2 O-PET [32,33,34] and with high reliability for [ 11 C]raclopride-PET [35]