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Animal studies use controlled purity, defined dosing, and monitoring that home use cannot replicate, and they still do not answer questions about long-term human exposure, immunogenicity, or rare serious events

Case Series and Pilot Studies: In recent years, a few small-scale human studies have surfaced, often by clinicians using BPC-157 in practice and then writing up their observations

Moreover, Mendelian randomization analyses support a causal role for specific gut microbes: Actinobacteria and Bifidobacterium taxa appear protective, while Lactobacillaceae increase anxiety risk (Lai and Xiong, 2025)