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Mounjaro, a dual GLP-1 and GIP receptor agonist licensed in the UK for type 2 diabetes mellitus, commonly affects gastrointestinal function during initial therapy

Natural GLP-1 has a short lifespan

Severe gastroparesis (delayed stomach emptying) : since GLP-1 further slows gastric motility, this can worsen symptoms significantly

FFA2 is activated predominantly by propionate and FFA3 by butyrate [EC 50 for acetate, propionate and butyrate at FFA2 are 431, 290 and 371 M respectively, and at FFA3 393, 41 and 33 M ( The gut microbiome is altered in obesity and T2D, an effect known as dysbiosis, where the ratio of the main bacterial phyla ( Firmicutes and Bacteroidetes ) becomes imbalanced, reducing diversity while the relative abundance of certain bacteria, including opportunistic pathogens, increases (Larsen et al., 2010)

Efficacy of individual and group hypnotherapy in irritable bowel syndrome (IMAGINE): a multicentre randomised controlled trial