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Elevated cortisol promotes fat storage (particularly visceral fat) and muscle catabolism, so ipamorelins ability to increase GH without raising cortisol is physiologically advantageous for patients focused on fat loss and lean mass preservation (4)

Ipamorelin distinguishes itself from other secretagogues due to its targeted action, stimulating GH release while minimally impacting cortisol, prolactin, and other stress-related hormones, offering one of the most favorable side effect profiles

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F.et al (2024)