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However, if a nodule grows large enough, it may lead to: Difficulty breathing or swallowing A feeling of fullness or tightness in the throat Hoarseness or changes in voice Neck pain or discomfort When a thyroid nodule produces excess thyroid hormone (a "hot" nodule), it can cause symptoms of hyperthyroidism, such as weight loss, muscle weakness, heat intolerance, anxiety, irritability, and irregular heartbeat