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An unexpected finding in our studies was the loss of improved lipid tolerance in Dpp4 EC/ mice, with or without coadministration of sitagliptin, following BMT, implying an interaction between bone marrowderived cells and the metabolic actions emanating from the reduction of DPP-4 activity in endothelial cells

Ceramide metabolism regulated by sphingomyelin synthase 2 is associated with acquisition of chemoresistance via exosomes in human leukemia cells

As previously reported [36], an increase in B220 + /CD43 + double-positive tumor cells was observed in the spleen of these mice at 3 weeks of age (Fig

Dapagliflozin effects on biomarkers, symptoms, and functional status in patients with heart failure with reduced ejection fraction: the DEFINE-HF trial

Statistical significance was tested using an unpaired two-tailed Students t test, a MannWhitney U test, a one-way or two-way ANOVA with Bonferroni correction or a KruskalWallis test followed by Dunns correction as indicated in the figure legend

Access this article Similar content being viewed by others Abbreviations AKT: Alpha serine/threonine-protein kinase AA: Arachidonic acid AEA: Anandamide CNRs: Cannabinoid receptors COX: Cyclooxygenase cPLA2: Cytosolic phospholipase A2 alpha cAMP: 3,5- cyclic adenosine monophosphate CREB: cAMP response element-binding protein DAG: Diacylglycerol ER: Endoplasmic reticulum GPCR: G-protein-coupled receptors ICSI: Intracytoplasmic Sperm Injection IP3: Inositol 1,4,5-trisphosphate LPA: Lysophosphatidic acid MAPK: Mitogen-activated protein kinase MLCK: Myosin light chain kinase NAPEPLD: N-acyl phosphatidylethanolamine phospholipase D NFAT: Nuclear factor of activated T-cells OTR: Oxytocin receptor PA: Phosphatidic acid PDK1: 3-phosphoinositide-dependent protein kinase 1 PG: Prostaglandin PIP2: Phosphatidylinositol 4, 5-bisphosphate PKA: Protein Kinase A PKC: Protein Kinase C PLA2: Phospholipase A2 PLC: Phospholipase C epsilon PLCL-1: Phospholipase C Like-1 PLC: Phospholipase C beta PLC: Phospholipase C Gamma PLC: Phospholipase C delta PLC: Phospholipase C zeta PLD: Phospholipase D RNE: Redundant Nuclear Envelope SOC: Store Operated Channel sPLA2: Secretory phospholipase A2 TRPM7: Transient receptor potential-melastatin-like 7 TRPV3: Transient receptor potential cation channel, subfamily V, member 3 VOCCs: Voltage-operated (L-type) calcium channels ZP: Zona pellucida References Inada M, Crowl RM, Bekkers ACAPA, Verheij H, Weiss J