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The etiologies of five congenital hypothyroid patients were unknown because these patients did not show positive test results for thyroid radionuclide uptake, thyroid sonography, or serum thyroglobulin, although they were kept on regular LT 4 therapy

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El uso prolongado de agonistas del receptor GLP-1 requiere vigilancia continua de efectos adversos, tanto comunes como raros pero potencialmente graves

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Clinical trials have demonstrated that certain GLP-1 receptor agonists reduce the risk of major adverse cardiovascular events in patients with type 2 diabetes and established cardiovascular disease

Summary: In Phase 2 clinical trials, retatrutide was typically initiated at 2 mg once weekly via subcutaneous injection, with gradual dose escalation over several months under close medical supervision