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Monitoring is reasonable

Data were analysed using one-way ANOVA with Bonferroni post hoc multiple-comparison test ( d , e , h ), two-way repeated-measures ANOVA ( a , c , f , g ), or Kruskall-Wallis test with uncorrected Dunnss test ( i )

injected with 1.5 10 11 genome copies per mouse of AAV8.TBG.pi.egfp.wpre.bgh (AAV-GFP

A separate 2024 study of 290 adults with obesity given oral semaglutide for three months found that free T3 decreased, free T4 rose slightly, and TSH fell during treatment

Limitations 1 : 1 : Results should be interpreted with caution because of the retrospective pre-post design without a control or comparator arm and the relatively short follow-up (6 months) Hypoglycemia may have been underreported, as only the clinically significant events were likely to have been captured (eg, no SMBG or CGM data) EMR database analysis as a potential for selection bias that cannot be controlled, as well as EMR data-capture challenges (eg, coding errors, no dosing data) Patients were mainly from the Northwest and Southern US states and therefore may not be representative of the US national landscape Sanofi-sponsored study *Follow-up period 6 months included GLP-1 RA + Toujeo (N=271)

As fumonisins inhibit sphingolipid biosynthesis, it is cited as a possible cause of neuronal tube defects (Lumsangkul et al., 2019)