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Then, GPR43 (50 nM), GPR109a (50 nM), and NC siRNA (50 nM) were delivered into the HepG2 cells (~40% confluent density) and cultured in Opti-MEM (Gibco) for 6 h, after which the transfection mixture was replaced with normal medium

It plays a crucial role in maintaining glucose homeostasis and energy balance (Ard, Jamy et al

Volke et al

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Glucose-dependent insulinotropic polypeptides add a second mechanism of action which affects the breakdown and transport of fat, which ultimately leads to lower body fat and weight loss

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