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These effects can include fatigue and weakness, numbness and tingling in the hands and feet, and memory loss and cognitive decline

Within each active month, the 5-days-on, 2-days-off schedule follows the same logic at the weekly level: it prevents tachyphylaxis (diminished response from constant exposure) while maintaining enough stimulus frequency to produce measurable visceral fat reduction

One study found that people with RA who started GLP-1 or SGLT2 medicine had fewer flares after starting treatment