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Association of metformin use and cancer incidence: a systematic review and meta-analysis

Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats

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Importantly, for many patients, heartburn and other gastrointestinal symptoms diminish over time as physiological adaptation occurs, though a subset of patients may experience persistent symptoms requiring intervention or medication discontinuation

Gastric bypass reduces fat intake and preference

I see GLP-1 therapy as complementary to those efforts, not a replacement