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It's like saying you're a bad designer, use less bold text, don't use italics in every other paragraph

These drugs were chosen because they represent different modes of action: paclitaxel and vincristine are microtubule-targeting agents, cisplatin forms covalent bonds with DNA and by that causes intra-strand and inter-strand cross-links that interfere with DNA replication and transcription, and doxorubicin intercalates into DNA and inhibiting topoisomerase II

Stress-associated chromatin modifications may also influence subsequent transcriptional responsiveness during prolonged or repeated stress exposure (Crisp et al., 2016

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doi: 10.3390/genes12101620 39 KozieE.Otulak-KozieK.BujarskiJ

C., Ding, C