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A recent review by Campbell [19] attempts to reconcile the paradoxical observations

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While small molecules like nicotine or estrogen can be absorbed via a patch, GLP-1 molecules are roughly ten times larger than the limit for skin absorption

Studies show that patients taking GLP-1 medications for weight loss can experience a reduction in body weight by 10-15% over a period of several months when combined with lifestyle interventions such as a healthy diet and exercise

Weight gain, cravings and fatigue are frustrating symptoms that many people deal with, and the idea that one plan could fix them all is compelling