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A total of 30 male BALB/c nude mice were randomly divided into four groups: a CT26 + 0.9%NaCl group (8 mice bearing CT26 tumors, treated with vehicle, as a control model of cancer cachexia), a 0.9%NaCl group (6 mice without tumors, treated with the vehicle, as normal controls), a CT26 + LC1 group (8 mice with CT26 tumors, treated with1 mg/kg bodyweight L-carnitine) and a CT26 + LC10 group (8 mice with CT26 tumors treated with10 mg/kg bodyweight L-carnitine)

This research may shed light on previous data identifying liver-derived IGF-I as one of the main factors in regulating the clearance of brain amyloid- (A) levels[68] and its potential implications in Alzheimers Disease (what will be further discussed in III.4.3.)

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The production process is regulated by enzymes such as tyrosinase, which plays a central role in converting the amino acid tyrosine into melanin

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