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After finding Ozempic ineffective, the 50-year-old Spelling gave the other GLP-1 a whirl and succeeded in losing weight

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In type 2 diabetes, glutathione depletion exacerbates hyperglycemia-induced ROS production, creating a feed-forward loop in which oxidative stress both results from and worsens insulin resistance (9)

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Doseresponse assays (30 pM1 M) were performed in duplicate with Ex-4 as a positive control