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However, this increase in melanin is not always desired, especially when it leads to conditions like dark spots, melasma, or other forms of skin discoloration

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As iron chelators also potentiated the effect of decitabine, this is another hint that treatment effects may be mediated by ROS and might also be influenced by the intracellular iron household

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Am J Hypertens 16(1):15 Yang W, Zhang J, Wang H, Shen W, Gao P, Singh M, Fang N (2011) Peroxisome proliferator-activated receptor regulates angiotensin II-induced catalase downregulation in adventitial fibroblasts of rats