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However, these treatments only produce modest results, and over 50% of patients do not achieve the desired effect size [34, 35]

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

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Permeability assays To establish the co-culture BBB model brain PCs were passaged at P11 (7 10 3 cells/insert) to the bottom (brain) side of culture inserts (polyester membrane

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This, besides suggesting a negative effect of MTX on cell cycle progression, highlighted the severity of the treatment conditions, which possibly resulted in a near complete cell cycle arrest