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Tirzepatide, the active ingredient in Mounjaro, produced high average results in the SURMOUNT-1 randomised controlled trial, with participants losing around 2022% of their body weight on average over 72 weeks

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When to Expect Symptom Relief During Treatment Week 12: Initial side effects appear shortly after your first injection

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10.1186/1471-2164-11-73 BMC Genomics 34 JiW.ZhuY.LiY.YangL.ZhaoX.CaiH.et al (2010)

Early research suggested GIP might promote fat storage, which initially made scientists skeptical about using GIP agonists for weight loss