It may cause side effects like nausea, prolonged erections, and gastrointestinal symptoms
GLP-1R agonists show great potential in AD, but key challenges, such as blood brain barrier (BBB) penetration, clinical trial inconsistency, long-term safety and precision therapy, need to be addressed
Nature 410 , 822825 (2001)
We will meet this challenge together
Notably, when Melanotan II-treated mice were compared to vehicle-treated pair-fed mice that lost equivalent body weight through caloric restriction, the Melanotan II group showed greater reductions in subcutaneous adipose tissue, suggesting effects beyond simple appetite suppression
Williams LD et al