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Side Effects of Higher Doses Common Side Effects The most common side effects of Wellbutrin treatment include: Drowsiness Insomnia Anxiety Excitement Gastrointestinal symptoms such as stomach pain, nausea, vomiting, constipation, loss of appetite, and weight loss Uncontrolled shaking Changes in taste Tinnitus (ringing in the ears) Sore throat These side effects usually get better in a week or two