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When energy is needed in a particular tissue, such as muscle, free fatty acids are taken up and oxidized

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Its pathogenesis is complex and multifaceted, encompassing multiple pathways, including systemic inflammation, microvascular lesions, endothelial dysfunction, hormonal abnormalities, neural factors, and psychosocial stress

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As tTG2 is vital to the development of celiac disease, selective inhibition of tTG2 could be another potential therapeutic approach for celiac disease (Kupfer 2012