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Augmented EMP flux in tumors induces concomitant upregulation of PFK1 expression, demonstrating a positive correlation with pathway metabolic efficiency [51]

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KRAS mutant cancer cell lines (HCT116 and Panc-1) were more sensitive to GSTO1 inhibition (Supplementary Table 25)

An additional aliquot was used for collagen determination after acid hydrolysis (Total Collagen Assay, Quickzyme Biosciences)

Moreover, we found that for both CD4 and CD8 CAR T cells, HK and G6PD expression levels showed a significant correlation, further supporting the potentially coupled activity of the two step-limiting rate enzymes of glycolysis and the PPP, respectively (Fig

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