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IGF-1 induced activation of IGF-1R led to AKT (Protein Kinase B) phosphorylation that may phosphorylate BAD (BCL2 Associated Death Promoter) and its dissociation from BCL2 to prevent apoptosis

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Results After 24 weeks of exercise intervention, Group 1 had higher height, serum IGF-1, and the growth value of molar ratio of IGF-1/IGFBP-3 than those of Group 2 and Group 3, with statistically significant difference between Group 1 and Group 3 (all p 0.05),