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Gasdermin D (GSDMD) and gasdermin E (GSDME), cleaved by Caspase 1 and Caspase 3 respectively, are two main discovered executors of pyroptosis [17, 52]

BPC-157 modulates serotonin in the gut as well as in the CNS (central nervous system)

632 Di-Huang-Yin-Zi effectively decreases ROS and MDA levels in prefrontal cortex, increases the expression of ferroptosis-related markers GPX4 and SLC7A11 and, and decreases iron deposition, thereby improving depressive symptoms and synaptic ultrastructure of cortical regions in post-stroke depressed (PSD) rats, suggesting that Di-Huang-Yin-Zi can reduce the symptoms and enhance function in PSD rats by inhibiting ferroptosis through SLC7A11/GPX4 pathway

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Wang, F., Li, X., Wang, X., & Jiang, X

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