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Khan MS, Fonarow GC, McGuire DK, Hernandez AF, Vaduganathan M, Rosenstock J, et al
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a recombinant analog of human IGF-1 with an 83-amino-acid sequence and an N-terminal extension that extends its half-life to approximately 2030 hours compared to endogenous IGF-1's 10-minute half-life
Moreover, in adoptive cell therapies (e.g., CAR-T, TCR-T, CAR-NK), modulation of CUL5 expression can significantly enhance immune-cell proliferation, cytokine secretion, and anti-tumor efficacy
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