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Glucuronidation is commonly present at low capacity in the fetus, newborns, and young infants, such that exposure to acetaminophen at these times leads to greater metabolism by other pathways

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Effector CD8+ T-cells are responsible for the destruction of melanocytes through the production of interferon gamma (IFN), release of granzymes and perforins, facilitated by T- regulatory (Treg) cell dysfunction

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