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The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

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The following information can be used to inform adjustment of background therapies in a patient starting a GLP-1 RA, with the approach individualized based on the specific needs of each patient

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