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Potential adverse effects and drug interactions: Gastrointestinal symptoms Cramping, diarrhoea, constipation, and abdominal discomfort are common, particularly at higher doses

Uzuner N, et al

The following GLP-1 (glucagon-like peptide-1) receptor agonists are FDA-approved for weight loss:[ref] Retatrutide is a GLP-1/GIP/GCG triple agonist that is currently in trials for weight loss and diabetes, showing promise for weight loss without muscle loss (2026)

Daily home dosing eliminates clinic visits required for IV administration

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