Melanotan II can cause adverse side effects, such as systemic toxicity, rhabdomyolysis, renal obstruction, and priapism
74 This is thought to be due to lower muscle cell energy production, leading to fatigue, and lactate and pyruvate build-up due to poor oxygen utilization in muscle tissue, leading to pain
That said, retatrutide is not FDA-approved yet
While both peptides share the goal of enhancing hormone release, their differences in potency, appetite stimulation, and secondary effects make them suited for distinct research purposes
EBioMedicine 63, 103202
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