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Currently used antidepressant drugs, which mostly target brain monoaminergic neurotransmission, have limited clinical efficacy

The result is a stronger collagen stimulus with a faster and calmer recovery than either intervention produces independently

Participants were randomized 2:1:1:1:1:2:2 to receive placebo or retatrutide at 1 mg, 4 mg (starting at 2 mg), 4 mg (starting at 4 mg), 8 mg (starting at 2 mg), 8 mg (starting at 4 mg), or 12 mg (starting at 2 mg) administered subcutaneously once weekly for 48 weeks