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Since they work using energy they can transport substances against the concentration gradients, some efflux pumps present on the BBB are P-glycoprotein (P-gp), the breast cancer resistance protein and various drug resistanceassociated protein, organic anion transporters, organic anion transporting polypeptides, etc
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(Among this group, 1.9 million also had diabetes, making them already eligible for Medicare coverage of other GLP-1 drugs approved for diabetes.) Although Wegovy already had FDA approval as an anti-obesity medication, Medicare is prohibited by law from covering drugs when prescribed for obesity