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This was addressed pharmacologically by identifying PAMs, including BPAM and the plant lectin Concanavalin A (ConA), which slowed down desensitization to the timescale of seconds (Gangwar et al., 2024b)
Pakravan N, Bateman DN, Goddard J
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Those who continued maintained their weight loss and reached 25.3% total reduction from baseline by week 88
Approximately 170 units
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