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Referral triggers include persistent hyperglycemia despite therapy, suspected pancreatitis, acute kidney injury, gallbladder disease, or concerning cardiovascular symptoms

Manson says

The biological mechanisms underlying weight regain involve complex adaptations in the body

The most common side effects in trials were gastrointestinal: nausea, diarrhea, constipation, vomiting, and decreased appetite

Additionally, improved glycemic control with GLP-1 RAs in T2DM patients may reduce glycosuria, a process known as glycemic buffering, which reduces caloric loss through urine and offsets part of the energy deficit induced by treatment [43,44,45]