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Limited Long-Term Data Mounjaro only approved in 2022 Zepbound only approved in 2023 Long-term safety profile still emerging Unknown effects of decades-long use 2

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The Study: Real-World Weight Loss Outcomes Researchers analyzed data from over 50,000 adults with obesity: 38,545 patients received a GLP-1 medication such as semaglutide or tirzepatide 12,540 patients underwent bariatric surgery, primarily gastric bypass or sleeve gastrectomy Key Findings : Surgery patients lost an average of 24% of their body weight over two years about 58 pounds