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CJC-1295, a synthetic analogue of growth hormone-releasing hormone (GHRH), demonstrates enhanced stability through DAC (Drug Affinity Complex) conjugation, while Ipamorelin functions as a selective ghrelin receptor agonist

However, in a mild acidic tumor microenvironment, the acid-labile -thiopropionate linker degrades, which results in mPEG shedding from the nanocomposites

The absence of these protective effects in SIRT1-knockout mice confirms the mechanisms specificity (95)

Mol Biochem Parasitol 39:155161

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