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Similarly, microdose scheduling can help maintain therapeutic effect while minimizing the peaks and troughs that contribute to both side effects and tolerance development

As a result, families and healthcare professionals have sought alternative approaches to complement the care of children with ADHD ( 18 - 19 )

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Renal function : Serum creatinine and estimated glomerular filtration rate (eGFR) should be monitored, especially in patients experiencing significant gastrointestinal adverse effects that may lead to dehydration

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Some natural ingredients were reported to target tyrosinase expression through MITF pathway, like resveratrol or -viniferin, a resveratrol oligomer that improved facial melasma and freckles [102]