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Always consult your healthcare provider before making any adjustments to your medication

For advanced disease, treatment may involve systemic immunotherapy (anti-PD-1, anti-CTLA-4 agents) or targeted therapy (for example, BRAF/MEK inhibitors in mutation-positive patients), both of which have significantly improved survival in recent years

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Such changes are commonly observed in neuropsychiatric disorders (for a review of these changes, see [153])

The GLP-1 context makes this nationally significant

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