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Lancet Diabetes Endocrinol (2019) 7:60617
Both are in phase 3 clinical trials
Research in Cell Metabolism (2022) demonstrated that GIP receptor agonism may paradoxically work in synergy with GLP-1 activity despite GIP being relatively less effective alone in obesity models, its combination with GLP-1 appears to amplify total metabolic response
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Tirzepatide appears to have a greater effect on glycemic control but retatrutide trials are still limited
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