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Peptide stability in gastric juice is documented - research confirms activity via subcutaneous and oral routes

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Transition metalbased carriers (e.g., MnO, Cu 2 , Fe 3 ) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors

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This stress-induced oxidative burden depletes glutathione reserves and may overwhelm cellular antioxidant defenses, potentially contributing to stress-related health consequences