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Phase 2 trials showed average weight loss of 24% at the highest dose over 48 weeks Significant improvements in blood glucose control and insulin sensitivity were observed Similar medications have shown PCOS-specific benefits including improved menstrual regularity Gastrointestinal side effects were most common but typically improved with continued use Specific PCOS trials are ongoing and will provide direct evidence for this population Comparing Retatrutide to Current PCOS Treatments Understanding how retatrutide fits into the current landscape of PCOS treatments helps frame its potential role in future management approaches
The goal is always the lowest effective dose that delivers meaningful outcomes
157 PochiniL.ScaliseM.GalluccioM.IndiveriC
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The diet restricts carbohydrates with an emphasis on eating unlimited fats and protein instead
binds GLP-1 receptors on pancreatic -cells (stimulating glucose-dependent insulin secretion), -cells (suppressing glucagon), gastrointestinal tract (slowing gastric emptying), and hypothalamic neurons (suppressing appetite and food intake via arcuate nucleus signaling)
