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doi: 10.3389/fphys.2018.00477 173 LuS

Glutathione depletion renders hepatocytes vulnerable to TNF-alpha-induced apoptosis, contributing to alcoholic hepatitis [6][35]

Basic Properties and Clinical Applications NIH

Glutathione is thought to influence pigmentation by: Inhibiting tyrosinase activity Shifting melanin production from eumelanin to pheomelanin Because of this, it is used for skin lightening in some settings

Meanwhile, IPN60090, also known as IACS-6274, has emerged as another promising GLS1 inhibitor, boasting favorable physicochemical properties and pharmacokinetic characteristics, coupled with a remarkable affinity for the target molecule [219, 220]

However, several factors support its safety profile