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They [the findings] suggest that this drug class, typically used for managing diabetes and obesity, may serve as a dual-purpose treatment for patients with RA, addressing both systemic inflammation and associated comorbidities, such as cardiovascular disease, which is especially prevalent in patients with RAO and remains the leading cause of death in patients with RA overall, they said

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Results indicated significant reductions in plasma TMAO and postprandial glucose levels after the plant-based diet, but TMAO levels increased after returning to the unrestricted diet

"Our findings highlight that, despite large increases in GLP-1 RA initiation, many patients stop these medications within a year, especially those without T2D, for whom insurance coverage may be limited, said Tricia Rodriguez, PhD, MPH, principal applied research scientist, Truveta and lead author of the study